Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known thiotepa products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
ADIENNE (Tepadina®)
Strength
Excipients
None
Osmolarity / osmolality
No information
pH
No information
Endotoxin content
No information
Strength
Excipients
Solvent: Sodium chloride, water for injection
Osmolarity / osmolality
No information
pH
No information
Endotoxin content
No information
Esteve Pharmaceuticals (formerly Intrapharm Laboratories)
Strength
Excipients
None
Osmolarity / osmolality
No information
pH
5.5 – 7.5 (0.02% solution)
Endotoxin content
≤0.34 IU/mg
Fresenius Kabi
Strength
Excipients
Sodium carbonate
Osmolarity / osmolality
240 – 320 mOsm/kg (after dilution)
pH
7.5 – 8.5
Endotoxin content
<0.38 EU/mg
Seacross Pharmaceuticals Ltd
Strength
Excipients
None
Osmolarity / osmolality
No information
pH
No information
Endotoxin content
No information
MSN Laboratories Europe Limited
Strength
Excipients
None
Osmolarity / osmolality
256 mOsmol/kg (diluted with 0.9% NaCl to a concentration of 1mg/ml)
pH
5.5-7.5
Endotoxin content
<0.208 IU/mg
Euro-Link Pharma Ltd
Strength
Excipients
None
Osmolarity / osmolality
No information
pH
No information
Endotoxin content
No information
Update history
- Republished
- Full monograph update
- Title and URL shortened.
- Advanz removed as discontinued by manufacturer
- Published