Depression and anxiety
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Choosing an antidepressant for people with coronary heart disease
29 April 2025Sertraline is the first-line option in people with coronary heart disease. Alternatives include fluoxetine, paroxetine and mirtazapine.
SSRI suggestions for adults with swallowing difficulties
20 June 2024A range of selective serotonin reuptake inhibitor (SSRI) formulations are suitable for adults with swallowing difficulties.
Switching strategies for antidepressants
22 May 2024The choice of antidepressant switching strategy depends on the person and antidepressant. We describe the current strategies and their application.
Deprescribing of antidepressants for depression and anxiety
4 December 2023Deprescribing antidepressants involves safely reducing and withdrawing them. An introduction; signposting to current resources; and SPS resources coming soon.
Using certain antidepressants during breastfeeding
15 November 2023Duloxetine, mirtazapine, trazodone or venlafaxine can be used with caution but other options are preferred. Recommendations apply to full term, healthy infants.
MAOI to other antidepressants: switching in adults
17 February 2023Switching between or from a monoamine oxidase inhibitor (MAOI) is a complex switch and requires support from a specialist. General principles are described.
Moclobemide to other antidepressants: switching in adults
17 February 2023Suggested methods for switching safely from moclobemide to other antidepressants. Switches requiring additional specialist support are highlighted.
Trazodone to other antidepressants: switching in adults
17 February 2023Suggested methods for switching safely from trazodone to other antidepressants. Switches requiring additional specialist support are highlighted.
Vortioxetine to other antidepressants: switching in adults
17 February 2023Suggested methods for switching safely from vortioxetine to other antidepressants. Switches requiring additional specialist support are highlighted.
SNRIs to other antidepressants: switching in adults
17 February 2023Suggested methods for switching safely between SNRIs or to other antidepressants. Switches requiring additional specialist support are highlighted.