Oxybutynin is preferred for urinary disorders during breastfeeding. Recommendations apply to full term and healthy infants only.

General considerations

It is important to complete an individual risk assessment for your patient and to apply the principles of prescribing in breastfeeding when looking at the available information and making treatment decisions.


Oxybutynin is the preferred choice for treating urinary frequency, urgency and urge incontinence due to its short half-life.

Effect on breastfeeding

There is a small risk that milk production could be decreased with medicines with an anticholinergic action (oxybutynin, darifenacin, and tolterodine), although there is no published evidence to support this.

Breastfed infants should be monitored for signs of the effects of decreased milk production if these medicines are used long term, e.g. poor weight gain.

Specific recommendations

Patient Information

The NHS website provides advice for patients on the use of specific medicines in breastfeeding.

Contact us

Get in touch with the UK Drugs In Lactation Advisory Service (UKDILAS), our specialist breastfeeding medicines advice service if you need support in the following situations:

  • you need further advice
  • the medicine in question is not included here
  • the infant is unwell or premature
  • multiple medicines are being taken

About our recommendations

Recommendations are based on published evidence where available. However, evidence is generally very poor and limited, and can require professional interpretation. Assessments are often based on reviewing case reports which can be conflicting and lack detail.

If there is no published clinical evidence, assessments are based on: pharmacodynamic and pharmacokinetic principles, extrapolation from similar drugs, risk assessment of normal clinical use, expert advice, and unpublished data. Simulated data is now increasingly being used due to the ethical difficulties around gathering good quality evidence in this area.


Full referencing is available on request.

Update history

  1. Update to mirabegron re amount likely to pass into milk.
  1. Minor title amendment
  1. Published