Lidocaine
ArticlesLactation Safety InformationNew Medicines · Published , updated
82573000
Articles
21 October 2020
Safety in Lactation: Drugs for rectal and anal disorders
Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Rectal glyceryl nitrate and diltiazem (unlicensed)… Benzyl benzoate Cinchocaine Diltiazem Glyceryl trinitrate Lidocaine Safety in Breastfeeding
15 October 2020
Safety in Lactation: Local anaesthetic eye preparations
Local anaesthetics for ophthalmic use have limited systemic absorption in the mother, and pose negligible risk to a breastfed infant. Systemic absorption from eye drops… Lidocaine Proxymetacaine Safety in Breastfeeding Tetracaine
25 September 2020
Safety in Lactation: Local anaesthesia
Local anaesthetics are generally considered to be compatible with breastfeeding. They are used in a variety of clinical situations (surgery including Caesarean sections, labour and… Bupivacaine Levobupivacaine Lidocaine Tetracaine
21 September 2020
Safety in Lactation: Drugs for oral ulceration and inflammation
The use of oropharyngeal anti-inflammatories/analgesics is not considered to present any risk to a breastfeeding infant. Doxycycline is considered to present negligible risk when used… Betamethasone Choline salicylate Doxycycline Flurbiprofen Hydrocortisone Lidocaine Salicylic acid
30 July 2020
What is the clinical significance of potential drug interactions with local anaesthetic preparations used in primary care dentistry?
This updated Medicines Q&A explores the clinical significance of potential interactions between dental local anaesthetic preparations and other medicines as listed in the BNF and… Adrenaline Articaine + Adrenaline Dentistry Interactions Lidocaine Lidocaine + Adrenaline Lidocaine + Prilocaine Mepivacaine Mepivacaine + Adrenaline Prilocaine Prilocaine + Felypressin Primary Care
25 March 2020
Reproductive Health Patient Group Direction (PGD) Templates
SPS and the Faculty of Sexual and Reproductive Health (FSRH), with the support of specialist stakeholders working within clinical practice, have produced PGD templates for… Azithromycin Ceftriaxone Community Health Services Desogestrel Doxycycline Emtricitabine + Tenofovir disoproxil Estradiol Estradiol + Dienogest Estradiol + Nomegestrol Ethinylestradiol Ethinylestradiol + Desogestrel Ethinylestradiol + Drospirenone Ethinylestradiol + Gestodene Ethinylestradiol + Levonorgestrel Ethinylestradiol + Norethisterone Ethinylestradiol + Norethisterone acetate Ethinylestradiol + Norgestimate Etonogestrel Family planning Health and Justice Hospital Pharmacy and Medicines Optimisation Programme (HOPMoP) Levonorgestrel Lidocaine Medroxyprogesterone Mental Health Metronidazole Norethisterone Patient Group Directions Primary Care Trusts UlipristalLactation Safety Information
Intravenous as anti-arrhythmic
Intravenous
as anti-arrhythmic
-
Small amounts in breast milk
Moderate published evidence of use in breastfeeding
Minimal absorption from the infant’s GI tract
Used in full-term neonates from birth
30 July 2020
For local anaesthesia
For local anaesthesia
Limited published evidence of safety
This entry applies to all uses (infiltration, regional and surface anaesthesia and nerve blocks) and formulations (injection/topical) of lidocaine for local anaesthesia, including injections with adrenaline
Small amounts in breast milk and minimal absorption from the infant’s GI tract
30 July 2020
For ophthalmic use
For ophthalmic use
Only available in combination with fluorescein for which there are no additional risks
30 July 2020
Ointment/spray for orophayngeal use
Ointment/spray for orophayngeal use
30 July 2020
Rectal
Rectal
-
Topical/rectal use for short periods in combination with a corticosteroid considered to present minimal risk to breastfed infant
30 July 2020
New Medicines
Topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age
Information
New formulation
Gedeon Richter
Not Known
Development and Regulatory status
Approved (Licensed)
None
None
Sep 20
No plans to launch in the UK anytime soon [4].
Jul 20
Lidocaine (Lidbree) 42 mg/mL intrauterine gel was approved in the UK for topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age [1].
Category
Lidocaine is a local anaesthetic of the amide type. Lidocaine reversibly stabilises neuronal membranes and prevents initiation and conduction of nerve impulses, thus providing local anaesthesia [1].
Some women feel no or only mild pain during a hysteroscopy, but for others the pain can be severe [2]. Cervical biopsy and cervical curettage are associated with visual analogue scale (VAS) pain scores ranging from four to six on a 10-point scale. Endometrial biopsies done have VAS scores of five to seven. Pain with intrauterine device insertion varies from two to seven, and pain scores during laminaria insertions with paracervical block range from five to seven [3].
Topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age
Intrauterine