Lidocaine

ArticlesLactation Safety InformationNew Medicines ·
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Articles

Lactation Safety Information

Intravenous as anti-arrhythmic

Intravenous
as anti-arrhythmic
-
Small amounts in breast milk
Moderate published evidence of use in breastfeeding
Minimal absorption from the infant’s GI tract
Used in full-term neonates from birth
30 July 2020

For local anaesthesia

For local anaesthesia
Limited published evidence of safety
This entry applies to all uses (infiltration, regional and surface anaesthesia and nerve blocks) and formulations (injection/topical) of lidocaine for local anaesthesia, including injections with adrenaline
Small amounts in breast milk and minimal absorption from the infant’s GI tract
30 July 2020

For ophthalmic use

For ophthalmic use
Only available in combination with fluorescein for which there are no additional risks
30 July 2020

Ointment/spray for orophayngeal use

Ointment/spray for orophayngeal use
30 July 2020

Rectal

Rectal
-
Topical/rectal use for short periods in combination with a corticosteroid considered to present minimal risk to breastfed infant
30 July 2020

New Medicines

Topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age

Information

New formulation
Gedeon Richter
Not Known

Development and Regulatory status

Approved (Licensed)
None
None
Sep 20No plans to launch in the UK anytime soon [4].
Jul 20Lidocaine (Lidbree) 42 mg/mL intrauterine gel was approved in the UK for topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age [1].

Category

Lidocaine is a local anaesthetic of the amide type. Lidocaine reversibly stabilises neuronal membranes and prevents initiation and conduction of nerve impulses, thus providing local anaesthesia [1].
Some women feel no or only mild pain during a hysteroscopy, but for others the pain can be severe [2]. Cervical biopsy and cervical curettage are associated with visual analogue scale (VAS) pain scores ranging from four to six on a 10-point scale. Endometrial biopsies done have VAS scores of five to seven. Pain with intrauterine device insertion varies from two to seven, and pain scores during laminaria insertions with paracervical block range from five to seven [3].
Topical anaesthesia for moderate acute pain during cervical and intrauterine procedures, in adults and adolescents from 15 years of age
Intrauterine

Evidence based evaluations

SPC