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What injections can be given orally or via enteral feeding tubes?

6 November 2020This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Not all enteral feeding…

What is the clinical significance of the interaction between methotrexate and penicillins?

1 October 2020The evidence for an interaction between methotrexate and penicillins is limited to case reports and animal studies. So far, there is no conclusive evidence that…

Suggestions for Therapeutic Drug Monitoring in Adults in Primary Care

29 September 2020This document is intended to support local discussions on how to monitor commonly prescribed high risk medicines in primary care.    The monitoring parameters cited…

Safety in Lactation: Antimetabolites

23 September 2020Antineoplastic antimetabolites, whether used as monotherapy or in combination with other antineoplastics, are contra-indicated in breastfeeding (except where indicated below) because of their effects on…

Should patients drink alcohol whilst taking long-term low-dose methotrexate?

22 September 2020This Medicines Q&A reviews the evidence that alcohol increases risk of methotrexate-induced liver toxicity, and advises on safe levels of alcohol intake by patients taking…
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Medicine Compliance Aid Stability

MaxtrexPharmacia Ltd

Pharmacia Ltd
Maxtrex
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are hygroscopic and cytotoxic.
11 February 2015

genericAmdipharm Mercury Co Ltd

Amdipharm Mercury Co Ltd
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are hygroscopic and cytotoxic.
11 February 2015

genericHospira UK

Hospira UK
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are hygroscopic and cytotoxic.
11 February 2015

genericOrion Pharma (UK) Ltd

Orion Pharma (UK) Ltd
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are hygroscopic and cytotoxic.
11 February 2015

genericSandoz Ltd

Sandoz Ltd
generic
Tablets 2.5mg, 10mg
R2 · Red 2Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Unsuitable
Tablets are hygroscopic and cytotoxic.
11 February 2015

Lactation Safety Information

As antineoplastic

As antineoplastic
Limited published evidence indicates small amounts in breast milk
If used as monotherapy, monitor infant’s blood count and do not resume breastfeeding until at least 4 days after a dose – longer with high doses
Discontinue breastfeeding if used in combination with other antineoplastics
17 September 2018

For rheumatoid arthritis

For rheumatoid arthritis
See summary
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
19 September 2019

For psoriasis

For psoriasis
Topical psoriasis preparation / corticosteroid if appropriate
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
16 September 2019

For inflammatory bowel disease

For inflammatory bowel disease
See summary
Limited published evidence indicates small amounts in breast milk after weekly administration
Monitor infant’s blood count and do not resume breastfeeding until at least 24 hours after a weekly dose not exceeding 25mg
16 September 2019