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Managing interactions with methotrexate

28 December 2023Guidance on frequently asked questions on medicine interactions with low dose methotrexate.

Using folic acid with methotrexate in rheumatoid arthritis

20 February 2023Folic acid is used to reduce methotrexate associated adverse effects in people with rheumatoid arthritis. This page guides appropriate dosing.

Accessing resources for patients on high risk medicines

19 December 2022A number of resources are available to support the safe use of high-risk medicines. Healthcare professionals should ensure they are available for their patients

Methotrexate: informing intrathecal risk assessment

11 August 2022Methotrexate products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Advising on missed or delayed doses of medicines

15 October 2021Guidance to advise people who occasionally forget or are late in taking a dose of their medicine(s).
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Lactation Safety Information

For rheumatoid arthritis

For rheumatoid arthritis
Very limited published evidence indicates negligible amounts in breast milk.
For doses of 25mg weekly or less, breastfeeding may continue with caution. However, breastfeeding should be withheld for a period of 24 hours after each dose.
Contact the UK Drugs in Lactation Advisory Service for doses exceeding 25mg weekly.
Monitor the infant for signs of immunosuppression and for gastrointestinal disturbances; the infant’s blood count should also be checked regularly.
16 February 2023