Using dosing tables to calculate total Cosmofer® dose

Iram Husain, Regional MI Manager/Pharmacist , London Medicines Information ServicePublished

Dosing tables enable you to determine a total Cosmofer® dose and decide whether or not you need to split the dose into two parts.

Use these tables as part of a process

The tables below are provided by the manufacturer and enable calculation of doses. The manufacturer’s tables present a dose rounded to the nearest ampoule volume to reduce Comosfer® wastage. They should be used as part of a fuller process for Cosmofer® dose calculation.

For target haemoglobin 11g/dL

The table enables estimation of the total iron requirements (mg) for target haemoglobin of 11g/dL. Shaded cells indicate where the dose exceeds 20mg/kg; these higher doses should be divided (as described in our article on the full Cosmofer® process).

Target haemoglobin 11g/dL

Body weight (kg)

Actual haemoglobin concentration (g/dL)

5
6
7
8
9
10
35
1000 900 800 700 600 500
40
1000 900 800 700 600 500
45
1100 1000 900 800 700 600
50
1200 1100 900 800 700 600
55
1200 1100 1000 800 700 600
60
1300 1200 1000 900 700 600
65
1400 1200 1100 900 800 600
70
1500 1300 1100 1000 800 600
75
1500 1400 1200 1000 800 600
80
1600 1400 1200 1000 800 600
85
1700 1500 1300 1100 900 700
90
1700 1500 1300 1100 900 700

For target haemoglobin 12g/dL

The table enables estimation of the total iron requirements (mg) for target haemoglobin of 12g/dL. Shaded cells indicate where the dose exceeds 20mg/kg; these higher doses should be divided (as described in our article on the full Cosmofer® process).

Target haemoglobin 12g/dL

Body weight (kg)

Actual haemoglobin concentration (g/dL)

6
7
8
9
10
11
35
1000 900 800 700 600 500
40
1000 900 800 700 600 500
45
1100 1000 900 800 700 600
50
1200 1100 900 800 700 600
55
1200 1100 1000 800 700 600
60
1300 1200 1000 900 700 600
65
1400 1200 1100 900 800 600
70
1500 1300 1100 1000 800 600
75
1500 1400 1200 1000 800 600
80
1600 1400 1200 1000 800 600
85
1700 1500 1300 1100 900 700
90
1700 1500 1300 1100 900 700

For target haemoglobin 13g/dL

The table enables estimation of the total iron requirements (mg) for target haemoglobin of 13g/dL. Shaded cells indicate where the dose exceeds 20mg/kg; these higher doses should be divided (as described in our article on the full Cosmofer® process).

Target haemoglobin 13g/dL

Body weight (kg)

Actual haemoglobin concentration (g/dL)

7
8
9
10
11
12
35
1000 900 800 700 600 500
40
1000 900 800 700 600 500
45
1100 1000 900 800 700 600
50
1200 1100 900 800 700 600
55
1200 1100 1000 800 700 600
60
1300 1200 1000 900 700 600
65
1400 1200 1100 900 800 600
70
1500 1300 1100 1000 800 600
75
1500 1400 1200 1000 800 600
80
1600 1400 1200 1000 800 600
85
1700 1500 1300 1100 900 700
90
1700 1500 1300 1100 900 700

For target haemoglobin 14g/dL

The table enables estimation of the total iron requirements (mg) for target haemoglobin of 14g/dL. Shaded cells indicate where the dose exceeds 20mg/kg; these higher doses should be divided (as described in our article on the full Cosmofer® process).

Target haemoglobin 14g/dL

Body weight (kg)

Actual haemoglobin concentration (g/dL)

7
8
9
10
11
12
13
35
1000 1000 900 800 700 600 500
40
1100 1000 900 800 700 600 500
45
1200 1100 1000 900 800 700 600
50
1300 1200 1100 900 800 700 600
55
1400 1200 1100 1000 800 700 600
60
1500 1300 1200 1000 900 700 600
65
1500 1400 1200 1100 900 800 600
70
1600 1500 1300 1100 1000 800 600
75
1700 1500 1400 1200 1000 800 600
80
1800 1600 1400 1200 1000 800 600
85
1900 1700 1500 1300 1100 900 700
90
2000 1700 1500 1300 1100 900 700

For target haemoglobin 15g/dL

The manufacturers of CosmoFer® provide a dosing table for patients with a target haemoglobin of 15.0g/dL, current iron level of 500mg and an actual body weight of 35kg to 90kg.

See the other steps in the process

Using the dosing tables forms part of the process of safely and effectively using Cosmofer. You should consult all the steps in our article on the topic.

Prescribing and giving CosmoFer® (iron dextran) as a total dose infusion

Use a stepped process to safely and rapidly correct iron deficiency in adults over 14 years in hospital.